Alaric Desmarchelier
Alaric Desmarchelier
SC CR Business Development Manager - Peptides Almac Sciences
Alaric Desmarchelier is an organic chemist by training, graduating with a PhD from the University of Versailles in 2012 in the field of organocatalysis. After several postdoctoral projects in the Netherlands, France and Spain on the applications of chirality in catalysis, material science and organic electronics, he joined Almac Sciences' in 2018 as a Peptide process development chemist, moving to Senior Scientist in 2020. In 2022, he joined the Business development team of Almac Sciences as a peptides technical expert Business development manager. Alaric also holds 16 peer-peer reviewed publications.
L19 - Unique challenges of peptide radiopharmaceuticals CMC in clinical development
Radiopharmaceutical peptides have become a focus point both in academic research and in clinical programs for imaging, therapeutic, or theranostic applications. Their success derives from a combination of a very selective ‘warhead’ peptide with a ‘payload’ tailored for low-background diagnosis and/or localised treatment. However, merging these features into one molecule brings unique challenges for the chemistry, manufacturing, and controls (CMC) arm of clinical development, requiring a tailored approach. This presentation will highlight the unique characteristics of radiopharmaceutical peptides from a chemistry and process development angle and will explore solutions to overcome these hurdles.