Leendert van den Bos
CEO
EnzyTag B.V.
The Netherlands
Leendert van den Bos obtained his MSc- and PhD-degree in bio-organic chemistry from Leiden University. He joined Organon BioSciences as a Scientist in 2007 and worked subsequently for Schering-Plough, Merck Sharp & Dohme and Aspen Pharmacare in roles with increasing responsibility.
From 2014 until 2018 he was head of the department Process Research and Development and was amongst other responsible for the GMP relocation of >20 API production routes to facilities in India and South-Africa.
In 2019 he co-founded EnzyTag. EnzyTag focuses on developing applications for the peptiligase enzymes for complex, long peptides and mini-proteins.
He is scientific advisor to the Radboud University in Nijmegen and involved in spinning out a biotech start-up that is developing small-molecule inhibitors in the immuno-oncology field.
L13 - Selected examples on the use of SPPS/CEPS in scale-up of peptides
This contribution will present selected examples on the use of SPPS/CEPS for the scalable and sustainable production of peptide API. The synthetic routes that will be discussed are straight-trough SPPS, fragment condensation using classical ligation strategies and fragment condensation using Chemo-Enzymatic Peptide Synthesis (ref Peptiligase).