Numaferm
Unlock the power of peptides, pepteins and proteins Don’t let cost stand in the way of innovation. Explore and harness the potential of affordable peptides, pepteins and proteins with our disruptive bioprocesses for discovery, optimization and production. Power innovation
Unlock the power of peptides, pepteins and proteins Don’t let cost stand in the way of innovation. Explore and harness the potential of affordable peptides, pepteins and proteins with our disruptive bioprocesses for discovery, optimization and production. Power innovation
Numaswitch™ Switch on the potential of inclusion bodies NumaswitchTM is changing the game, making inclusion bodies accessible. Often regarded as waste during recombinant production, inclusion bodies are expressed in high titers, making them revolutionary to the production of peptides and proteins at scale.
Numaswitch enables up to 100% refolding efficiencies of inclusion bodies. Make use of Numaswitch for efficient inclusion body-based production processes for the first time ever.
The Switchtag is a nature-evolved sensor reacting towards Ca2+ ions Access the full power of recombinant processes In the absence of Ca2+ ions the Switchtag has an unstructured conformation that forces inclusion body formation. In presence of Ca2+ ions the Switchtag folds into a stable, water-soluble functional protein.
Cost-of-Goods Produce high-quality peptides and proteins quickly, at scale and with reduced costs. Numaswitch™ serves as a unique high-titer expression platform enabling material supply in a short timeframe, at needed scales, reduced costs and the highest qualities. Evolved by nature, discovered by leading scientists, optimized and applied by Numaferm.
Quality Ensure success with the highest service standards Numaferm is an ISO 9001:2015 certified company dedicated to quality and customer satisfaction. With a track record of over 200 successful projects, Numaferm has become a trusted partner in the industry. Sustainability Sustainable production: ecological, economical, responsible Sustainable and future-proof, NumaswitchTM reduces your carbon footprint and leaves out fine chemicals and organic solvents to meet higher safety standards.
Cell Line & Process Development Programs Numaswitch™ We apply the NumaswitchTM expression platform to ensure the delivery of your target at scale, on time and at the highest quality possible. Commercial/GMP supply Industry-grade processes and access to broad partner network The commercial and/or GMP production is realized by our established partner network of well-known CMO companies. Our production processes are industry-grade and ready to be transferred to production plants.
Cell Line & Process Development Patent protected Numaswitch™ is designed for any E. coli strain. The high-titer production of your target is managed by the intrinsic expression machinery. Just send us your preferred strain and we are happy to ignite its potential with Numaswitch™ 1 month Cell Line Development The high-titer production of your target is managed by the intrinsic expression machinery, establishing a standardized workflow to define the perfect cell line within as little as 1 month. This cell line may be used to supply 1-5 mgs of your target. NumaswitchTM is applicable for any E. coli strain. Just send us your preferred strain and let NumaswitchTM ignite its potential. 2 months Implementation of Analytics From research grade to clinical material, we develop all needed analytical methods to meet the highest quality standards. This includes common analytics known for biologics like residual host cell proteins, DNA and endotoxins, as well as analytics known for small molecules such as HPLC, IC chromatography, AAA and many more. Optimization and Upscaling Our production platform and expertise enable the application of standardized workflows in each unique project. In as little as 2 months production processes in the g scale are developed, ensuring up-scalability and cost-efficiency, while meeting highest product and process standards. Research cell banks (RCB), master cell banks (MCB) and working cell banks (WCB) are deviated in early phases of the project to ensure on time delivery of pre-clinical, GMP and commercial material. 1 month Material Supply for GxP studies Up to 100 g of your target is produced in accordance with our quality management system (ISO 9001:2015) suitable for pre-clinical studies and field trials. Production is based on standard operation procedures (SOPs) and qualified research cell banks (RCB).
Commercial and GMP supply The upscalability of NumaswitchTM has been proven in the multi 1,000 l fermentation scale. Developed processes meet the highest quality expectations, such as drug substances standards, and are GMP-conform. All material and information are ready for process transfer into commercial plants. We select your preferred contract manufacturing organization (CMO) for the commercial and/or GMP production from our network, including well-known industry leaders.
Numacut TEV Protease, 6x His-Tag The Numacut TEV protease is the first protease platform to produce native proteins. Evolved by applying artificial intelligence and directed evolution, the recognition site from TEV protease (ENLYFQ/S) was broadened to ENLYFQ/X (X: any amino acid, except I and P). Because of this new recognition site, your target is fused C-terminal to ENLYFQ and is cleaved-off by Numacut TEV protease independently of the N-terminal amino acid.

Numaferm GmbH  Biomade Innovation

Merowingerplatz 1a, 40225 Düsseldorf

www.numaferm.com


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