Jonathan M Collins
Senior VP of Business Development
CEM Corporation
USA
Jonathan M. Collins is the VP of Business Development for CEM Corporation. His research focuses on developing methodological improvements for peptide synthesis focusing on novel coupling chemistries, resins, and instrumentation. Since 2011, he has served as the Director of Business Development at CEM with responsibility for New Product Development and Marketing Strategy for Peptides. He earned his B.S. in Chemistry from the University of Florida, M.S. in Materials Science from Stanford University, and MBA from the Kellogg School of Management at Northwestern University.
L06 - Re imagining Peptide Synthesis with UE-SPPS
This presentation presents an ultra-efficient (UE-SPPS) process that, for the first time, eliminates all washing steps for standard Fmoc chemistry along with merging the coupling and deprotection steps into a continuous one-pot process under microwave SPPS conditions. A fundamental breakthrough of UE-SPPS is the elimination of the Fmoc removal base used without any washing. This was successfully applied to a broad range of sequences with lengths up to 89 amino acids and included the glucagon like peptide (GLP)-1, liraglutide. All peptides were obtained in high purity, fast synthesis times and without any washing using UE-SPPS.
The introduction of a large-scale microwave peptide synthesizer with reaction vessel sizes up to 15 liters allows UE-SPPS to become applicable for not only research production, but also large-scale cGMP peptide production. At these larger scales, both higher crude purities and solvent savings of multi-hundreds of liters per peptide batch can be realized by using UE-SPPS.