Walter Cabri
Professor
University of Bologna
Italy
After 35 years in the industry mainly in large (Pharmacia; BMS, Fresenius Kabi; Farmitalia Carlo Erba/Pharmacia; Sigma tau) and medium size (Antibioticos; Indena) companies Walter joined, as Full Professor of Organic Chemistry, the Alma Mater Studiorum-University of Bologna. The main areas of interest are in the fields of drug discovery (oncology, CNS, antibacterial agents, Malaria), protein-protein interactions, pharmaceutical green chemistry, peptides and complex drugs as well as catalysis. Awards: Federchimica Prize (1993 Anthracyclines chemistry); Ciamician Medal (1995 SCI for the work in organometallic catalysis); Bristol-Myers Squibb President Award (1996); Prize for the Industrial Application of Organic Chemistry (2013 SCI/Organic Chemistry Division). Co-author of 140 papers; 108 patents; one Book “From Bench to Market” Oxford University Press 2000.
L12 - The jigsaw puzzle of greeness in peptides synthesis
Developing greener synthetic processes in the pharmaceutical sector is an inescapable necessity to transform the industrial landscape into a long term sustainable reality.1 In this context, the renaissance of peptides as medical treatments and the enforcement of more stringent regulatory requirements by Regulatory Agencies, pushed chemists to develop more sustainable processes to prepare highly pure active pharmaceutical ingredients. The recent evolution of Liquid Phase Peptide Synthesis (LPPS), Solid Phase Peptide Synthesis (SPPS) and Chem Enzymatic Peptide Synthesis (CEPS) will be discussed.2
1. Cabri,W.; Cantelmi,P.; Corbisiero,D.; Fantoni,T.; Ferrazzano,L.; Martelli,G.; Mattellone,A.; Tolomelli,A. Frontiers in Mol Bios. 2021, 8, art.6975586. 2. a. Ferrazzano,L.; Catani,M.; Cavazzini,A.; Martelli,G.; Corbisiero,D.; Cantelmi,P.; Fantoni,T.; Mattellone,A.; De Luca,C.; Felletti,S.; Cabri,W.; Tolomelli,A. Green Chemistry 2022,24,975-1020.